Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin
- Autores: Vasin M.1, Gan’shina T.2, Mirzoyan R.2, Semenova L.1, Koroleva L.1, Afanas’ev R.1, Ushakov I.1
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Afiliações:
- State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- V. V. Zakusov Research Institute of Pharmacology
- Edição: Volume 165, Nº 3 (2018)
- Páginas: 364-367
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240312
- DOI: https://doi.org/10.1007/s10517-018-4171-1
- ID: 240312
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Resumo
We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector.
Sobre autores
M. Vasin
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Autor responsável pela correspondência
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
T. Gan’shina
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
R. Mirzoyan
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
L. Semenova
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
L. Koroleva
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
R. Afanas’ev
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
I. Ushakov
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Rússia, Moscow
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