Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo
- Авторы: Kurskaya O.1, Murashkina T.1, Alekseev A.1, Sharshov K.1, Romakh L.1, Derko A.1, Troitskii A.1, Bystrova T.1, Shkurupy V.1,2, Shestopalov A.1
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Учреждения:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 165, № 2 (2018)
- Страницы: 248-251
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240200
- DOI: https://doi.org/10.1007/s10517-018-4140-8
- ID: 240200
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Аннотация
Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
Об авторах
O. Kurskaya
Research Institute of Experimental and Clinical Medicine
Автор, ответственный за переписку.
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
T. Murashkina
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
A. Alekseev
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
K. Sharshov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
L. Romakh
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
A. Derko
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
T. Bystrova
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk
V. Shkurupy
Research Institute of Experimental and Clinical Medicine; Novosibirsk Medical University, Ministry of Health of the Russian Federation
Email: kurskaya_og@mail.ru
Россия, Novosibirsk; Novosibirsk
A. Shestopalov
Research Institute of Experimental and Clinical Medicine
Email: kurskaya_og@mail.ru
Россия, Novosibirsk