Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses
- Авторы: Demkin V.1, Udut V.1,2, Shchetinin P.1, Svetlik M.1, Mel’nichuk S.1, Shchetinina A.1, Pleshkov M.1, Starkov D.1, Demkin O.1, Kingma H.1,3
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Учреждения:
- National Research Tomsk State University
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
- Выпуск: Том 164, № 6 (2018)
- Страницы: 707-711
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239870
- DOI: https://doi.org/10.1007/s10517-018-4063-4
- ID: 239870
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Аннотация
We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain—phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.
Об авторах
V. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: wospp@yandex.ru
Россия, Tomsk; Tomsk
P. Shchetinin
National Research Tomsk State University
Автор, ответственный за переписку.
Email: wospp@yandex.ru
Россия, Tomsk
M. Svetlik
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
S. Mel’nichuk
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
A. Shchetinina
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
M. Pleshkov
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
D. Starkov
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
O. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
Россия, Tomsk
H. Kingma
National Research Tomsk State University; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: wospp@yandex.ru
Россия, Tomsk; Maastricht