Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses
- 作者: Demkin V.1, Udut V.1,2, Shchetinin P.1, Svetlik M.1, Mel’nichuk S.1, Shchetinina A.1, Pleshkov M.1, Starkov D.1, Demkin O.1, Kingma H.1,3
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隶属关系:
- National Research Tomsk State University
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
- 期: 卷 164, 编号 6 (2018)
- 页面: 707-711
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239870
- DOI: https://doi.org/10.1007/s10517-018-4063-4
- ID: 239870
如何引用文章
详细
We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain—phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.
作者简介
V. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk; Tomsk
P. Shchetinin
National Research Tomsk State University
编辑信件的主要联系方式.
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
M. Svetlik
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
S. Mel’nichuk
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
A. Shchetinina
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
M. Pleshkov
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
D. Starkov
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
O. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk
H. Kingma
National Research Tomsk State University; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: wospp@yandex.ru
俄罗斯联邦, Tomsk; Maastricht