Electrophysiological Properties of Rat Vestibular Labyrinth and Their Effect on Parameters of Transmitted Voltage Pulses
- Авторлар: Demkin V.1, Udut V.1,2, Shchetinin P.1, Svetlik M.1, Mel’nichuk S.1, Shchetinina A.1, Pleshkov M.1, Starkov D.1, Demkin O.1, Kingma H.1,3
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Мекемелер:
- National Research Tomsk State University
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
- Шығарылым: Том 164, № 6 (2018)
- Беттер: 707-711
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239870
- DOI: https://doi.org/10.1007/s10517-018-4063-4
- ID: 239870
Дәйексөз келтіру
Аннотация
We propose a new approach to optimization of electrical stimulation of the vestibular nerve and improving the transfer function of vestibular implant. A mathematical model of the vestibular organ is developed based on its anatomy, the model premises, 3D-analysis of MRI and CT images, and mathematical description of physical processes underlying propagation of alternating electric current across the tissues of vestibular labyrinth. This approach was tested in vitro on the rat vestibular apparatus and had been examined anatomically prior to the development of its mathematical model and equivalent electrical circuit. The experimental and theoretical values of changes of the gain—phase characteristics of vestibular tissues in relation to location of the reference electrode obtained in this study can be used to optimize the electrical stimulation of vestibular nerve.
Авторлар туралы
V. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
V. Udut
National Research Tomsk State University; E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: wospp@yandex.ru
Ресей, Tomsk; Tomsk
P. Shchetinin
National Research Tomsk State University
Хат алмасуға жауапты Автор.
Email: wospp@yandex.ru
Ресей, Tomsk
M. Svetlik
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
S. Mel’nichuk
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
A. Shchetinina
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
M. Pleshkov
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
D. Starkov
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
O. Demkin
National Research Tomsk State University
Email: wospp@yandex.ru
Ресей, Tomsk
H. Kingma
National Research Tomsk State University; Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, School for Mental Health and Neuroscience
Email: wospp@yandex.ru
Ресей, Tomsk; Maastricht