Effects of Multicide, Antibacterial Drug, on Staphylococcus Biomembranes


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Аннотация

Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.

Об авторах

G. Tetz

Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation

Email: vtetzv@yahoo.com
Россия, St. Petersburg

N. Artemenko

Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation

Email: vtetzv@yahoo.com
Россия, St. Petersburg

G. Yankovskii

MISiS National Research Technological Institute

Email: vtetzv@yahoo.com
Россия, Moscow

L. Kever

Institute of Cytology, the Russian Academy of Sciences

Email: vtetzv@yahoo.com
Россия, St. Petersburg

Ya. Komissarchik

Institute of Cytology, the Russian Academy of Sciences

Email: vtetzv@yahoo.com
Россия, St. Petersburg

V. Tetz

Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation

Автор, ответственный за переписку.
Email: vtetzv@yahoo.com
Россия, St. Petersburg


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