Effects of Multicide, Antibacterial Drug, on Staphylococcus Biomembranes
- Авторы: Tetz G.1, Artemenko N.1, Yankovskii G.2, Kever L.3, Komissarchik Y.3, Tetz V.1
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Учреждения:
- Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
- MISiS National Research Technological Institute
- Institute of Cytology, the Russian Academy of Sciences
- Выпуск: Том 163, № 6 (2017)
- Страницы: 780-784
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239252
- DOI: https://doi.org/10.1007/s10517-017-3902-z
- ID: 239252
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Аннотация
Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.
Об авторах
G. Tetz
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Email: vtetzv@yahoo.com
Россия, St. Petersburg
N. Artemenko
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Email: vtetzv@yahoo.com
Россия, St. Petersburg
G. Yankovskii
MISiS National Research Technological Institute
Email: vtetzv@yahoo.com
Россия, Moscow
L. Kever
Institute of Cytology, the Russian Academy of Sciences
Email: vtetzv@yahoo.com
Россия, St. Petersburg
Ya. Komissarchik
Institute of Cytology, the Russian Academy of Sciences
Email: vtetzv@yahoo.com
Россия, St. Petersburg
V. Tetz
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: vtetzv@yahoo.com
Россия, St. Petersburg