Effects of Multicide, Antibacterial Drug, on Staphylococcus Biomembranes
- Authors: Tetz G.V.1, Artemenko N.K.1, Yankovskii G.M.2, Kever L.V.3, Komissarchik Y.Y.3, Tetz V.V.1
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Affiliations:
- Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
- MISiS National Research Technological Institute
- Institute of Cytology, the Russian Academy of Sciences
- Issue: Vol 163, No 6 (2017)
- Pages: 780-784
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239252
- DOI: https://doi.org/10.1007/s10517-017-3902-z
- ID: 239252
Cite item
Abstract
Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.
About the authors
G. V. Tetz
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Email: vtetzv@yahoo.com
Russian Federation, St. Petersburg
N. K. Artemenko
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Email: vtetzv@yahoo.com
Russian Federation, St. Petersburg
G. M. Yankovskii
MISiS National Research Technological Institute
Email: vtetzv@yahoo.com
Russian Federation, Moscow
L. V. Kever
Institute of Cytology, the Russian Academy of Sciences
Email: vtetzv@yahoo.com
Russian Federation, St. Petersburg
Ya. Yu. Komissarchik
Institute of Cytology, the Russian Academy of Sciences
Email: vtetzv@yahoo.com
Russian Federation, St. Petersburg
V. V. Tetz
Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation
Author for correspondence.
Email: vtetzv@yahoo.com
Russian Federation, St. Petersburg