Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease
- Авторы: Gruzdeva O.1, Akbasheva O.2, Dyleva Y.1, Antonova L.1, Matveeva V.1, Uchasova E.1, Fanaskova E.1, Karetnikova V.1, Ivanov S.1, Barbarash O.1
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Учреждения:
- Research Institute of Complex Problems of Cardiovascular Diseases
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 163, № 5 (2017)
- Страницы: 608-611
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239121
- DOI: https://doi.org/10.1007/s10517-017-3860-5
- ID: 239121
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Аннотация
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
Об авторах
O. Gruzdeva
Research Institute of Complex Problems of Cardiovascular Diseases
Автор, ответственный за переписку.
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
O. Akbasheva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: o_gruzdeva@mail.ru
Россия, Tomsk
Yu. Dyleva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
L. Antonova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
V. Matveeva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
E. Uchasova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
E. Fanaskova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
V. Karetnikova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
S. Ivanov
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo
O. Barbarash
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Россия, Kemerovo