Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease
- Авторлар: Gruzdeva O.1, Akbasheva O.2, Dyleva Y.1, Antonova L.1, Matveeva V.1, Uchasova E.1, Fanaskova E.1, Karetnikova V.1, Ivanov S.1, Barbarash O.1
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Мекемелер:
- Research Institute of Complex Problems of Cardiovascular Diseases
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 163, № 5 (2017)
- Беттер: 608-611
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239121
- DOI: https://doi.org/10.1007/s10517-017-3860-5
- ID: 239121
Дәйексөз келтіру
Аннотация
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
Авторлар туралы
O. Gruzdeva
Research Institute of Complex Problems of Cardiovascular Diseases
Хат алмасуға жауапты Автор.
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
O. Akbasheva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: o_gruzdeva@mail.ru
Ресей, Tomsk
Yu. Dyleva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
L. Antonova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
V. Matveeva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
E. Uchasova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
E. Fanaskova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
V. Karetnikova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
S. Ivanov
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo
O. Barbarash
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Ресей, Kemerovo