Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease
- Autores: Gruzdeva O.1, Akbasheva O.2, Dyleva Y.1, Antonova L.1, Matveeva V.1, Uchasova E.1, Fanaskova E.1, Karetnikova V.1, Ivanov S.1, Barbarash O.1
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Afiliações:
- Research Institute of Complex Problems of Cardiovascular Diseases
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 163, Nº 5 (2017)
- Páginas: 608-611
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239121
- DOI: https://doi.org/10.1007/s10517-017-3860-5
- ID: 239121
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Resumo
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
Sobre autores
O. Gruzdeva
Research Institute of Complex Problems of Cardiovascular Diseases
Autor responsável pela correspondência
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
O. Akbasheva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: o_gruzdeva@mail.ru
Rússia, Tomsk
Yu. Dyleva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
L. Antonova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
V. Matveeva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
E. Uchasova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
E. Fanaskova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
V. Karetnikova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
S. Ivanov
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo
O. Barbarash
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Rússia, Kemerovo