Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease
- Authors: Gruzdeva O.V.1, Akbasheva O.E.2, Dyleva Y.A.1, Antonova L.V.1, Matveeva V.G.1, Uchasova E.G.1, Fanaskova E.V.1, Karetnikova V.N.1, Ivanov S.V.1, Barbarash O.L.1
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Affiliations:
- Research Institute of Complex Problems of Cardiovascular Diseases
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 5 (2017)
- Pages: 608-611
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239121
- DOI: https://doi.org/10.1007/s10517-017-3860-5
- ID: 239121
Cite item
Abstract
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
About the authors
O. V. Gruzdeva
Research Institute of Complex Problems of Cardiovascular Diseases
Author for correspondence.
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
O. E. Akbasheva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: o_gruzdeva@mail.ru
Russian Federation, Tomsk
Yu. A. Dyleva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
L. V. Antonova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
V. G. Matveeva
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
E. G. Uchasova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
E. V. Fanaskova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
V. N. Karetnikova
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
S. V. Ivanov
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo
O. L. Barbarash
Research Institute of Complex Problems of Cardiovascular Diseases
Email: o_gruzdeva@mail.ru
Russian Federation, Kemerovo