New Silk Fibroin-Based Bioresorbable Microcarriers
- Авторы: Arkhipova A.1, Kotlyarova M.1, Novichkova S.1, Agapova O.2, Kulikov D.3, Kulikov A.4, Drutskaya M.5, Agapov I.2, Moisenovich M.1
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Учреждения:
- Biological Faculty, M. V. Lomonosov Moscow State University
- V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Выпуск: Том 160, № 4 (2016)
- Страницы: 491-494
- Раздел: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236752
- DOI: https://doi.org/10.1007/s10517-016-3204-x
- ID: 236752
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Аннотация
We fabricated bioresorbable microcarriers from water solution of Bombyx mori silk fi broin. The microcarriers are 3D structures with intricate surface and pores allowing penetration of culture medium, gas exchange, and cell adhesion. Fibroin molecules form hydrophobic structures and normally have a negative charge, which stimulates migration, but inhibits cell adhesion and makes it less effective. In order to improve adhesion efficiency and velocity, gelatin (hydrophilic biopolymer with integrin-recognizing RGD sequence) was added to the microcarrier composition. The resultant bioresorbable microcarriers support adhesion and proliferation of 3T3 murine fibroblasts.
Об авторах
A. Arkhipova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Россия, Moscow
M. Kotlyarova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Россия, Moscow
S. Novichkova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Россия, Moscow
O. Agapova
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor_agapov@mail.ru
Россия, Moscow
D. Kulikov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: igor_agapov@mail.ru
Россия, Moscow
A. Kulikov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: igor_agapov@mail.ru
Россия, Moscow
M. Drutskaya
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: igor_agapov@mail.ru
Россия, Moscow
I. Agapov
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: igor_agapov@mail.ru
Россия, Moscow
M. Moisenovich
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Россия, Moscow