New Silk Fibroin-Based Bioresorbable Microcarriers
- Autores: Arkhipova A.1, Kotlyarova M.1, Novichkova S.1, Agapova O.2, Kulikov D.3, Kulikov A.4, Drutskaya M.5, Agapov I.2, Moisenovich M.1
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Afiliações:
- Biological Faculty, M. V. Lomonosov Moscow State University
- V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 491-494
- Seção: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236752
- DOI: https://doi.org/10.1007/s10517-016-3204-x
- ID: 236752
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Resumo
We fabricated bioresorbable microcarriers from water solution of Bombyx mori silk fi broin. The microcarriers are 3D structures with intricate surface and pores allowing penetration of culture medium, gas exchange, and cell adhesion. Fibroin molecules form hydrophobic structures and normally have a negative charge, which stimulates migration, but inhibits cell adhesion and makes it less effective. In order to improve adhesion efficiency and velocity, gelatin (hydrophilic biopolymer with integrin-recognizing RGD sequence) was added to the microcarrier composition. The resultant bioresorbable microcarriers support adhesion and proliferation of 3T3 murine fibroblasts.
Sobre autores
A. Arkhipova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Rússia, Moscow
M. Kotlyarova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Rússia, Moscow
S. Novichkova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Rússia, Moscow
O. Agapova
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor_agapov@mail.ru
Rússia, Moscow
D. Kulikov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: igor_agapov@mail.ru
Rússia, Moscow
A. Kulikov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: igor_agapov@mail.ru
Rússia, Moscow
M. Drutskaya
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: igor_agapov@mail.ru
Rússia, Moscow
I. Agapov
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: igor_agapov@mail.ru
Rússia, Moscow
M. Moisenovich
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
Rússia, Moscow