New Silk Fibroin-Based Bioresorbable Microcarriers
- 作者: Arkhipova A.1, Kotlyarova M.1, Novichkova S.1, Agapova O.2, Kulikov D.3, Kulikov A.4, Drutskaya M.5, Agapov I.2, Moisenovich M.1
-
隶属关系:
- Biological Faculty, M. V. Lomonosov Moscow State University
- V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- 期: 卷 160, 编号 4 (2016)
- 页面: 491-494
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236752
- DOI: https://doi.org/10.1007/s10517-016-3204-x
- ID: 236752
如何引用文章
详细
We fabricated bioresorbable microcarriers from water solution of Bombyx mori silk fi broin. The microcarriers are 3D structures with intricate surface and pores allowing penetration of culture medium, gas exchange, and cell adhesion. Fibroin molecules form hydrophobic structures and normally have a negative charge, which stimulates migration, but inhibits cell adhesion and makes it less effective. In order to improve adhesion efficiency and velocity, gelatin (hydrophilic biopolymer with integrin-recognizing RGD sequence) was added to the microcarrier composition. The resultant bioresorbable microcarriers support adhesion and proliferation of 3T3 murine fibroblasts.
作者简介
A. Arkhipova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
M. Kotlyarova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
S. Novichkova
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
O. Agapova
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
D. Kulikov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
A. Kulikov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
M. Drutskaya
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
I. Agapov
V. I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow
M. Moisenovich
Biological Faculty, M. V. Lomonosov Moscow State University
Email: igor_agapov@mail.ru
俄罗斯联邦, Moscow