Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study
- Autores: Serebryakova V.1, Urazova O.1, Novitsky V.1, Vengerovskii A.1, Kononova T.1, Vasil’eva O.1, Beresneva A.1
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Afiliações:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 168, Nº 1 (2019)
- Páginas: 109-112
- Seção: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/242270
- DOI: https://doi.org/10.1007/s10517-019-04659-x
- ID: 242270
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Resumo
The effects of a fluroquinolone levofloxacin on apoptosis of peripheral blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led to an increase in the number of CD95+ and AnnV+ lymphocytes. In patients with drug-resistant form of tuberculosis, only the number of apoptotic lymphocytes, but not the count of CD95+ cells increased under these conditions.
Sobre autores
V. Serebryakova
Siberian State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: serebryakova-val@mail.ru
Rússia, Tomsk
O. Urazova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk
V. Novitsky
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk
A. Vengerovskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk
T. Kononova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk
O. Vasil’eva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk
A. Beresneva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Rússia, Tomsk