Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study
- Authors: Serebryakova V.A.1, Urazova O.I.1, Novitsky V.V.1, Vengerovskii A.I.1, Kononova T.E.1, Vasil’eva O.A.1, Beresneva A.E.1
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 168, No 1 (2019)
- Pages: 109-112
- Section: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/242270
- DOI: https://doi.org/10.1007/s10517-019-04659-x
- ID: 242270
Cite item
Abstract
The effects of a fluroquinolone levofloxacin on apoptosis of peripheral blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led to an increase in the number of CD95+ and AnnV+ lymphocytes. In patients with drug-resistant form of tuberculosis, only the number of apoptotic lymphocytes, but not the count of CD95+ cells increased under these conditions.
About the authors
V. A. Serebryakova
Siberian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
O. I. Urazova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
V. V. Novitsky
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
A. I. Vengerovskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
T. E. Kononova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
O. A. Vasil’eva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
A. E. Beresneva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: serebryakova-val@mail.ru
Russian Federation, Tomsk
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