Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice
- Autores: Davydova T.1, Gruden M.2, Kudrin V.3, Narkevich V.3, Vetrile L.1, Zakharova I.1, Sewell R.4
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Afiliações:
- Research Institute of General Pathology and Pathophysiology
- P. K. Anokhin Research Institute of Normal Physiology
- V. V. Zakusov Research Institute of Pharmacology
- School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
- Edição: Volume 166, Nº 3 (2019)
- Páginas: 326-329
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240995
- DOI: https://doi.org/10.1007/s10517-019-04343-0
- ID: 240995
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Resumo
Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
Sobre autores
T. Davydova
Research Institute of General Pathology and Pathophysiology
Autor responsável pela correspondência
Email: dav-ta@yandex.ru
Rússia, Moscow
M. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Email: dav-ta@yandex.ru
Rússia, Moscow
V. Kudrin
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
Rússia, Moscow
V. Narkevich
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
Rússia, Moscow
L. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
Rússia, Moscow
I. Zakharova
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
Rússia, Moscow
R. Sewell
School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
Email: dav-ta@yandex.ru
Reino Unido da Grã-Bretanha e Irlanda do Norte, Cardiff
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