Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice
- Authors: Davydova T.V.1, Gruden M.A.2, Kudrin V.S.3, Narkevich V.B.3, Vetrile L.A.1, Zakharova I.A.1, Sewell R.D.4
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Affiliations:
- Research Institute of General Pathology and Pathophysiology
- P. K. Anokhin Research Institute of Normal Physiology
- V. V. Zakusov Research Institute of Pharmacology
- School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
- Issue: Vol 166, No 3 (2019)
- Pages: 326-329
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240995
- DOI: https://doi.org/10.1007/s10517-019-04343-0
- ID: 240995
Cite item
Abstract
Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
About the authors
T. V. Davydova
Research Institute of General Pathology and Pathophysiology
Author for correspondence.
Email: dav-ta@yandex.ru
Russian Federation, Moscow
M. A. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Email: dav-ta@yandex.ru
Russian Federation, Moscow
V. S. Kudrin
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
Russian Federation, Moscow
V. B. Narkevich
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
Russian Federation, Moscow
L. A. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
Russian Federation, Moscow
I. A. Zakharova
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
Russian Federation, Moscow
R. D. E. Sewell
School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
Email: dav-ta@yandex.ru
United Kingdom, Cardiff
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