Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice
- 作者: Davydova T.1, Gruden M.2, Kudrin V.3, Narkevich V.3, Vetrile L.1, Zakharova I.1, Sewell R.4
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隶属关系:
- Research Institute of General Pathology and Pathophysiology
- P. K. Anokhin Research Institute of Normal Physiology
- V. V. Zakusov Research Institute of Pharmacology
- School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
- 期: 卷 166, 编号 3 (2019)
- 页面: 326-329
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240995
- DOI: https://doi.org/10.1007/s10517-019-04343-0
- ID: 240995
如何引用文章
详细
Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
作者简介
T. Davydova
Research Institute of General Pathology and Pathophysiology
编辑信件的主要联系方式.
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
M. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
V. Kudrin
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
V. Narkevich
V. V. Zakusov Research Institute of Pharmacology
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
L. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
I. Zakharova
Research Institute of General Pathology and Pathophysiology
Email: dav-ta@yandex.ru
俄罗斯联邦, Moscow
R. Sewell
School of Pharmacy and Pharmaceutical Sciences, Cardiff Universit
Email: dav-ta@yandex.ru
英国, Cardiff
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