Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny
- Autores: Yaglova N.1, Tsomartova D.1, Obernikhin S.1, Nazimova S.1, Yaglov V.1
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Afiliações:
- Laboratory of Endocrine System Development, Research Institute of Human Morphology
- Edição: Volume 166, Nº 2 (2018)
- Páginas: 283-286
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240969
- DOI: https://doi.org/10.1007/s10517-018-4333-1
- ID: 240969
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Resumo
We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foci were revealed in the outer zona fasciculata. In rats exposed to DDT during the prenatal and postnatal periods, compensatory increase in secretory activity of cells due to increase in mitochondria content was noted in the inner zona fasciculata, which determined elevated serum concentration of corticosterone. In rats exposed to DDT only during the postnatal development, functional activity of zona fasciculata cells was suppressed, which attested to delayed upregulation of secretion.
Sobre autores
N. Yaglova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Autor responsável pela correspondência
Email: yaglova@mail.ru
Rússia, Moscow
D. Tsomartova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Rússia, Moscow
S. Obernikhin
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Rússia, Moscow
S. Nazimova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Rússia, Moscow
V. Yaglov
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Rússia, Moscow
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