Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny
- Authors: Yaglova N.V.1, Tsomartova D.A.1, Obernikhin S.S.1, Nazimova S.V.1, Yaglov V.V.1
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Affiliations:
- Laboratory of Endocrine System Development, Research Institute of Human Morphology
- Issue: Vol 166, No 2 (2018)
- Pages: 283-286
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240969
- DOI: https://doi.org/10.1007/s10517-018-4333-1
- ID: 240969
Cite item
Abstract
We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foci were revealed in the outer zona fasciculata. In rats exposed to DDT during the prenatal and postnatal periods, compensatory increase in secretory activity of cells due to increase in mitochondria content was noted in the inner zona fasciculata, which determined elevated serum concentration of corticosterone. In rats exposed to DDT only during the postnatal development, functional activity of zona fasciculata cells was suppressed, which attested to delayed upregulation of secretion.
About the authors
N. V. Yaglova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Author for correspondence.
Email: yaglova@mail.ru
Russian Federation, Moscow
D. A. Tsomartova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. S. Obernikhin
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. V. Nazimova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
V. V. Yaglov
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow