Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny
- 作者: Yaglova N.1, Tsomartova D.1, Obernikhin S.1, Nazimova S.1, Yaglov V.1
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隶属关系:
- Laboratory of Endocrine System Development, Research Institute of Human Morphology
- 期: 卷 166, 编号 2 (2018)
- 页面: 283-286
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240969
- DOI: https://doi.org/10.1007/s10517-018-4333-1
- ID: 240969
如何引用文章
详细
We studied secretory activity of adrenal zona fasciculata cells in pubertal rats exposed to low doses of endocrine disrupter DDT during prenatal and postnatal periods and only during postnatal period. In exposed animals, circulatory disturbances leading to degeneration and necrosis of cells as well as regeneration foci were revealed in the outer zona fasciculata. In rats exposed to DDT during the prenatal and postnatal periods, compensatory increase in secretory activity of cells due to increase in mitochondria content was noted in the inner zona fasciculata, which determined elevated serum concentration of corticosterone. In rats exposed to DDT only during the postnatal development, functional activity of zona fasciculata cells was suppressed, which attested to delayed upregulation of secretion.
作者简介
N. Yaglova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
编辑信件的主要联系方式.
Email: yaglova@mail.ru
俄罗斯联邦, Moscow
D. Tsomartova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
俄罗斯联邦, Moscow
S. Obernikhin
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
俄罗斯联邦, Moscow
S. Nazimova
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
俄罗斯联邦, Moscow
V. Yaglov
Laboratory of Endocrine System Development, Research Institute of Human Morphology
Email: yaglova@mail.ru
俄罗斯联邦, Moscow
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