Enviar artigo por via de e-mail Mechanisms of Granulocytopoiesis Recovery Stimulation with Filgrastim in Breast Cancer Patients Receiving Chemotherapy
- Autores: Goldberg V.1, Polyakova T.2,3, Popova N.1, Vysotskaya V.1, Simolina E.1, Dudnikova E.1, Goncharova N.1, Belevich Y.1, Tuzikova T.2, Goldberg A.1, Miroshnichenko L.2, Udut E.2, Simanina E.2, Zyuz’kov G.2, Zhdanov V.2, Dygai A.1
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Afiliações:
- Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
- National Research Tomsk State University
- Edição: Volume 166, Nº 1 (2018)
- Páginas: 63-68
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/240835
- DOI: https://doi.org/10.1007/s10517-018-4290-8
- ID: 240835
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Resumo
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
Sobre autores
V. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: center@tnimc.ru
Rússia, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences; National Research Tomsk State University
Email: center@tnimc.ru
Rússia, Tomsk; Tomsk
N. Popova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
V. Vysotskaya
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
E. Simolina
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
E. Dudnikova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
N. Goncharova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
Yu. Belevich
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
T. Tuzikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
A. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
A. Dygai
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Rússia, Tomsk
