电邮这篇文章 Mechanisms of Granulocytopoiesis Recovery Stimulation with Filgrastim in Breast Cancer Patients Receiving Chemotherapy
- 作者: Goldberg V.1, Polyakova T.2,3, Popova N.1, Vysotskaya V.1, Simolina E.1, Dudnikova E.1, Goncharova N.1, Belevich Y.1, Tuzikova T.2, Goldberg A.1, Miroshnichenko L.2, Udut E.2, Simanina E.2, Zyuz’kov G.2, Zhdanov V.2, Dygai A.1
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隶属关系:
- Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
- National Research Tomsk State University
- 期: 卷 166, 编号 1 (2018)
- 页面: 63-68
- 栏目: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/240835
- DOI: https://doi.org/10.1007/s10517-018-4290-8
- ID: 240835
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详细
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
作者简介
V. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences; National Research Tomsk State University
Email: center@tnimc.ru
俄罗斯联邦, Tomsk; Tomsk
N. Popova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
V. Vysotskaya
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
E. Simolina
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
E. Dudnikova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
N. Goncharova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
Yu. Belevich
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
T. Tuzikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
A. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
A. Dygai
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
俄罗斯联邦, Tomsk
