Мақаланы E-mail арқылы жіберу Mechanisms of Granulocytopoiesis Recovery Stimulation with Filgrastim in Breast Cancer Patients Receiving Chemotherapy
- Авторлар: Goldberg V.1, Polyakova T.2,3, Popova N.1, Vysotskaya V.1, Simolina E.1, Dudnikova E.1, Goncharova N.1, Belevich Y.1, Tuzikova T.2, Goldberg A.1, Miroshnichenko L.2, Udut E.2, Simanina E.2, Zyuz’kov G.2, Zhdanov V.2, Dygai A.1
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Мекемелер:
- Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
- National Research Tomsk State University
- Шығарылым: Том 166, № 1 (2018)
- Беттер: 63-68
- Бөлім: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/240835
- DOI: https://doi.org/10.1007/s10517-018-4290-8
- ID: 240835
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
Авторлар туралы
V. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: center@tnimc.ru
Ресей, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences; National Research Tomsk State University
Email: center@tnimc.ru
Ресей, Tomsk; Tomsk
N. Popova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
V. Vysotskaya
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
E. Simolina
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
E. Dudnikova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
N. Goncharova
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
Yu. Belevich
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
T. Tuzikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
A. Goldberg
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
A. Dygai
Research Institute of Oncology, Tomsk Research Medical Center of the Russian Academy of Sciences
Email: center@tnimc.ru
Ресей, Tomsk
