Mitigating Effect of Nitrates (Monizol) on Pharmacodynamic Shifts in the Cardiovascular System Caused by Radioprotector Indralin
- Authors: Vasin M.V.1, Gan’shina T.S.2, Mirzoyan R.S.2, Semenova L.A.1, Koroleva L.V.1, Afanas’ev R.V.1, Ushakov I.B.1
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Affiliations:
- State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 165, No 3 (2018)
- Pages: 364-367
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240312
- DOI: https://doi.org/10.1007/s10517-018-4171-1
- ID: 240312
Cite item
Abstract
We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector.
About the authors
M. V. Vasin
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Author for correspondence.
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
T. S. Gan’shina
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
R. S. Mirzoyan
V. V. Zakusov Research Institute of Pharmacology
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
L. A. Semenova
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
L. V. Koroleva
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
R. V. Afanas’ev
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow
I. B. Ushakov
State Research Centre F. M. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: mikhail-v-vasin@yandex.ru
Russian Federation, Moscow