Homer 1a Induces Calcium Channel Activation, but Does Not Change Their Properties in A431 Cells
- Autores: Shalygin A.1, Ryazantseva M.1, Glushankova L.1, Gusev K.1, Kolesnikov D.1, Vigont V.1, Skopin A.1, Skobeleva K.1, Kaznacheeva E.1
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Afiliações:
- Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
- Edição: Volume 165, Nº 2 (2018)
- Páginas: 272-275
- Seção: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/240222
- DOI: https://doi.org/10.1007/s10517-018-4146-2
- ID: 240222
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Resumo
Store-operated channels activated in response to intracellular calcium store depletion represent the main pathway of calcium entry from the extracellular space in nonelectroexcitable cells. Adapter proteins organize the components of this system into integral complex. We studied the influence of adapter proteins of the Homer family on endogenous store-operated calcium Imin channels in A431 cells. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
Sobre autores
A. Shalygin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Autor responsável pela correspondência
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
M. Ryazantseva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
L. Glushankova
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
K. Gusev
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
D. Kolesnikov
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
V. Vigont
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
A. Skopin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
K. Skobeleva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg
E. Kaznacheeva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Rússia, St. Petersburg