Homer 1a Induces Calcium Channel Activation, but Does Not Change Their Properties in A431 Cells
- Авторлар: Shalygin A.1, Ryazantseva M.1, Glushankova L.1, Gusev K.1, Kolesnikov D.1, Vigont V.1, Skopin A.1, Skobeleva K.1, Kaznacheeva E.1
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Мекемелер:
- Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
- Шығарылым: Том 165, № 2 (2018)
- Беттер: 272-275
- Бөлім: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/240222
- DOI: https://doi.org/10.1007/s10517-018-4146-2
- ID: 240222
Дәйексөз келтіру
Аннотация
Store-operated channels activated in response to intracellular calcium store depletion represent the main pathway of calcium entry from the extracellular space in nonelectroexcitable cells. Adapter proteins organize the components of this system into integral complex. We studied the influence of adapter proteins of the Homer family on endogenous store-operated calcium Imin channels in A431 cells. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
Авторлар туралы
A. Shalygin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
M. Ryazantseva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
L. Glushankova
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
K. Gusev
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
D. Kolesnikov
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
V. Vigont
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
A. Skopin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
K. Skobeleva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg
E. Kaznacheeva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Ресей, St. Petersburg