Homer 1a Induces Calcium Channel Activation, but Does Not Change Their Properties in A431 Cells
- Authors: Shalygin A.V.1, Ryazantseva M.A.1, Glushankova L.N.1, Gusev K.O.1, Kolesnikov D.O.1, Vigont V.A.1, Skopin A.Y.1, Skobeleva K.V.1, Kaznacheeva E.V.1
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Affiliations:
- Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
- Issue: Vol 165, No 2 (2018)
- Pages: 272-275
- Section: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/240222
- DOI: https://doi.org/10.1007/s10517-018-4146-2
- ID: 240222
Cite item
Abstract
Store-operated channels activated in response to intracellular calcium store depletion represent the main pathway of calcium entry from the extracellular space in nonelectroexcitable cells. Adapter proteins organize the components of this system into integral complex. We studied the influence of adapter proteins of the Homer family on endogenous store-operated calcium Imin channels in A431 cells. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
About the authors
A. V. Shalygin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Author for correspondence.
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
M. A. Ryazantseva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
L. N. Glushankova
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
K. O. Gusev
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
D. O. Kolesnikov
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
V. A. Vigont
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
A. Yu. Skopin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
K. V. Skobeleva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg
E. V. Kaznacheeva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
Russian Federation, St. Petersburg