Homer 1a Induces Calcium Channel Activation, but Does Not Change Their Properties in A431 Cells


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Store-operated channels activated in response to intracellular calcium store depletion represent the main pathway of calcium entry from the extracellular space in nonelectroexcitable cells. Adapter proteins organize the components of this system into integral complex. We studied the influence of adapter proteins of the Homer family on endogenous store-operated calcium Imin channels in A431 cells. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.

作者简介

A. Shalygin

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

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Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

M. Ryazantseva

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

L. Glushankova

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

K. Gusev

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

D. Kolesnikov

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

V. Vigont

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

A. Skopin

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

K. Skobeleva

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

E. Kaznacheeva

Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences

Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg

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