Homer 1a Induces Calcium Channel Activation, but Does Not Change Their Properties in A431 Cells
- 作者: Shalygin A.V.1, Ryazantseva M.A.1, Glushankova L.N.1, Gusev K.O.1, Kolesnikov D.O.1, Vigont V.A.1, Skopin A.Y.1, Skobeleva K.V.1, Kaznacheeva E.V.1
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隶属关系:
- Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
- 期: 卷 165, 编号 2 (2018)
- 页面: 272-275
- 栏目: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/240222
- DOI: https://doi.org/10.1007/s10517-018-4146-2
- ID: 240222
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详细
Store-operated channels activated in response to intracellular calcium store depletion represent the main pathway of calcium entry from the extracellular space in nonelectroexcitable cells. Adapter proteins organize the components of this system into integral complex. We studied the influence of adapter proteins of the Homer family on endogenous store-operated calcium Imin channels in A431 cells. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
作者简介
A. Shalygin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
M. Ryazantseva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
L. Glushankova
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
K. Gusev
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
D. Kolesnikov
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
V. Vigont
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
A. Skopin
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
K. Skobeleva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
E. Kaznacheeva
Laboratory of Cell Membrane Ionic Channels, Institute of Cytology of Russian Academy of Sciences
Email: a_shalygin@mail.ru
俄罗斯联邦, St. Petersburg
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