NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood
- Авторлар: Kuzmina U.1, Zainullina L.1, Sadovnikov S.1, Vakhitov V.1, Vakhitova Y.1
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Мекемелер:
- Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
- Шығарылым: Том 165, № 2 (2018)
- Беттер: 252-255
- Бөлім: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240208
- DOI: https://doi.org/10.1007/s10517-018-4141-7
- ID: 240208
Дәйексөз келтіру
Аннотация
To determine the role of NMDA receptors in the functional regulation of immunocompetent cells, comparative assay was carried out for genes expressed in the mononuclears in peripheral blood of healthy persons under normal conditions and after blockade of these receptors. The genes, whose expression changed in response to blockade of NMDA receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (IL4, VCAM1, and CDKN2A), apoptosis (BAX, MYC, CDKN2A, HSPB1, and CADD45A), activation (IL4R, IL4, VCAM1, and CDKN2A), and differentiation (IL4, VCAM1, and BAX).
Авторлар туралы
U. Kuzmina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Ресей, Ufa
L. Zainullina
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Ресей, Ufa
S. Sadovnikov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Ресей, Ufa
V. Vakhitov
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Email: juvv73@gmail.com
Ресей, Ufa
Yu. Vakhitova
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: juvv73@gmail.com
Ресей, Ufa