Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress
- Autores: Kolesnikova L.1, Rychkova L.1, Kolesnikova L.1,2, Darenskaya M.1, Natyaganova L.1, Grebenkina L.1, Korytov L.2, Kolesnikov S.1,3
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Afiliações:
- Research Center of Family Health and Human Reproduction
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- M. V. Lomonosov Moscow State University
- Edição: Volume 164, Nº 6 (2018)
- Páginas: 712-715
- Seção: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239871
- DOI: https://doi.org/10.1007/s10517-018-4064-3
- ID: 239871
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Resumo
Mature normotensive male WAG rats and stress-sensitive hypertensive ISIAH rats were exposed to “everyday life stress” modelled by alternation of immobilization and adaptation. Increased LPO intensity (increased content of substrates with unsaturated double bonds and primary and secondary LPO products) and reduced content of some antioxidant protection components (reduced retinol level and GSH/GSSG ratio) were revealed in the blood of ISIAH rats. These changes correlated with elevated mean BP. The results can reflect the significant role of LPO changes in the pathogenesis of stress-induced arterial hypertension.
Sobre autores
L. Kolesnikova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Rychkova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction; Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk; Irkutsk
M. Darenskaya
Research Center of Family Health and Human Reproduction
Autor responsável pela correspondência
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Natyaganova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Grebenkina
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
S. Kolesnikov
Research Center of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk; Moscow
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