Email this article Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress
- Authors: Kolesnikova L.I.1, Rychkova L.V.1, Kolesnikova L.R.1,2, Darenskaya M.A.1, Natyaganova L.V.1, Grebenkina L.A.1, Korytov L.I.2, Kolesnikov S.I.1,3
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Affiliations:
- Research Center of Family Health and Human Reproduction
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- M. V. Lomonosov Moscow State University
- Issue: Vol 164, No 6 (2018)
- Pages: 712-715
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239871
- DOI: https://doi.org/10.1007/s10517-018-4064-3
- ID: 239871
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Abstract
Mature normotensive male WAG rats and stress-sensitive hypertensive ISIAH rats were exposed to “everyday life stress” modelled by alternation of immobilization and adaptation. Increased LPO intensity (increased content of substrates with unsaturated double bonds and primary and secondary LPO products) and reduced content of some antioxidant protection components (reduced retinol level and GSH/GSSG ratio) were revealed in the blood of ISIAH rats. These changes correlated with elevated mean BP. The results can reflect the significant role of LPO changes in the pathogenesis of stress-induced arterial hypertension.
About the authors
L. I. Kolesnikova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. V. Rychkova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. R. Kolesnikova
Research Center of Family Health and Human Reproduction; Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk; Irkutsk
M. A. Darenskaya
Research Center of Family Health and Human Reproduction
Author for correspondence.
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. V. Natyaganova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. A. Grebenkina
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
L. I. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk
S. I. Kolesnikov
Research Center of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Russian Federation, Irkutsk; Moscow
