Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress
- 作者: Kolesnikova L.1, Rychkova L.1, Kolesnikova L.1,2, Darenskaya M.1, Natyaganova L.1, Grebenkina L.1, Korytov L.2, Kolesnikov S.1,3
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隶属关系:
- Research Center of Family Health and Human Reproduction
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- M. V. Lomonosov Moscow State University
- 期: 卷 164, 编号 6 (2018)
- 页面: 712-715
- 栏目: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239871
- DOI: https://doi.org/10.1007/s10517-018-4064-3
- ID: 239871
如何引用文章
详细
Mature normotensive male WAG rats and stress-sensitive hypertensive ISIAH rats were exposed to “everyday life stress” modelled by alternation of immobilization and adaptation. Increased LPO intensity (increased content of substrates with unsaturated double bonds and primary and secondary LPO products) and reduced content of some antioxidant protection components (reduced retinol level and GSH/GSSG ratio) were revealed in the blood of ISIAH rats. These changes correlated with elevated mean BP. The results can reflect the significant role of LPO changes in the pathogenesis of stress-induced arterial hypertension.
作者简介
L. Kolesnikova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
L. Rychkova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction; Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk; Irkutsk
M. Darenskaya
Research Center of Family Health and Human Reproduction
编辑信件的主要联系方式.
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
L. Natyaganova
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
L. Grebenkina
Research Center of Family Health and Human Reproduction
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
L. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk
S. Kolesnikov
Research Center of Family Health and Human Reproduction; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
俄罗斯联邦, Irkutsk; Moscow