Ultrastructure of Rat Kidneys after Intravenous Administration of Modified Magnetite Nanoparticles


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Resumo

The ultrastructure of nephrocytes of the proximal and distal convoluted tubules, podocytes, mesangial cells, and macrophages of the interstitial connective tissue was studied after single intravenous administration of magnetite nanoparticles modified with chitosan (magnetic nanospheres) or lipids (magnetic liposomes). Transmission electron microscopy showed ultrastructural features of absorption of magnetite nanoparticles. The shape, size, and number of vesicles containing nanoparticles in nephrocytes of convoluted tubules and macrophages after administration of the suspensions of magnetic nanospheres and magnetic liposomes were described.

Sobre autores

I. Mil’to

Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation; Department of Biotechnology and Organic Chemistry

Autor responsável pela correspondência
Email: milto_bio@mail.ru
Rússia, Tomsk; Tomsk

I. Sukhodolo

Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation

Email: milto_bio@mail.ru
Rússia, Tomsk

V. Ivanova

Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation

Email: milto_bio@mail.ru
Rússia, Tomsk

M. Yusubov

Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation; Department of Technology of Organic Substances and Polymeric Materials, National Research Tomsk Polytechnic University

Email: milto_bio@mail.ru
Rússia, Tomsk; Tomsk


Declaração de direitos autorais © Springer Science+Business Media, LLC, part of Springer Nature, 2017

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