Email this article Ultrastructure of Rat Kidneys after Intravenous Administration of Modified Magnetite Nanoparticles
- Authors: Mil’to I.V.1,2, Sukhodolo I.V.1, Ivanova V.V.1, Yusubov M.S.1,3
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Affiliations:
- Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation
- Department of Biotechnology and Organic Chemistry
- Department of Technology of Organic Substances and Polymeric Materials, National Research Tomsk Polytechnic University
- Issue: Vol 164, No 2 (2017)
- Pages: 218-222
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239515
- DOI: https://doi.org/10.1007/s10517-017-3962-0
- ID: 239515
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Abstract
The ultrastructure of nephrocytes of the proximal and distal convoluted tubules, podocytes, mesangial cells, and macrophages of the interstitial connective tissue was studied after single intravenous administration of magnetite nanoparticles modified with chitosan (magnetic nanospheres) or lipids (magnetic liposomes). Transmission electron microscopy showed ultrastructural features of absorption of magnetite nanoparticles. The shape, size, and number of vesicles containing nanoparticles in nephrocytes of convoluted tubules and macrophages after administration of the suspensions of magnetic nanospheres and magnetic liposomes were described.
About the authors
I. V. Mil’to
Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation; Department of Biotechnology and Organic Chemistry
Author for correspondence.
Email: milto_bio@mail.ru
Russian Federation, Tomsk; Tomsk
I. V. Sukhodolo
Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation
Email: milto_bio@mail.ru
Russian Federation, Tomsk
V. V. Ivanova
Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation
Email: milto_bio@mail.ru
Russian Federation, Tomsk
M. S. Yusubov
Department of Morphology and General Pathology, Siberian State Medical University, Ministry of the Health of the Russian Federation; Department of Technology of Organic Substances and Polymeric Materials, National Research Tomsk Polytechnic University
Email: milto_bio@mail.ru
Russian Federation, Tomsk; Tomsk
