Oxidative Stress as a Mechanisms of Reduced Glucose Absorption under Conditions of Immobilization Stress
- Autores: Kolesnikova L.1, Kolesnikov S.1,2, Korytov L.3, Suslikova M.3, Darenskaya M.1, Grebenkina L.1, Kolesnikova L.1
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Afiliações:
- Research Center of Family Health and Human Reproduction Problems
- M. V. Lomonosov Moscow State University
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 164, Nº 2 (2017)
- Páginas: 132-135
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239420
- DOI: https://doi.org/10.1007/s10517-017-3941-5
- ID: 239420
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Resumo
Experimental studies demonstrated inhibition of glucose absorption in the jejunum in acute and chronic 1-h daily immobilization stress, with the maximum inhibition on day 7 of immobilization. These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the primary and end LPO products and decrease of the total antioxidant activity of the blood. Correction of these shifts with the antioxidant drug inhibits accumulation of LPO products and increases antioxidant defense and glucose absorption rate. These data prove the important role of peroxidation in regulation of glucose absorption.
Sobre autores
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
S. Kolesnikov
Research Center of Family Health and Human Reproduction Problems; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk; Moscow
L. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
M. Suslikova
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
M. Darenskaya
Research Center of Family Health and Human Reproduction Problems
Autor responsável pela correspondência
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Grebenkina
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Rússia, Irkutsk