Oxidative Stress as a Mechanisms of Reduced Glucose Absorption under Conditions of Immobilization Stress
- Авторы: Kolesnikova L.I.1, Kolesnikov S.I.1,2, Korytov L.I.3, Suslikova M.I.3, Darenskaya M.A.1, Grebenkina L.A.1, Kolesnikova L.R.1
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Учреждения:
- Research Center of Family Health and Human Reproduction Problems
- M. V. Lomonosov Moscow State University
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 164, № 2 (2017)
- Страницы: 132-135
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239420
- DOI: https://doi.org/10.1007/s10517-017-3941-5
- ID: 239420
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Аннотация
Experimental studies demonstrated inhibition of glucose absorption in the jejunum in acute and chronic 1-h daily immobilization stress, with the maximum inhibition on day 7 of immobilization. These changes correlate with the development of oxidative stress in animals over the entire duration of the experiment, which manifested by an increase in the content of the primary and end LPO products and decrease of the total antioxidant activity of the blood. Correction of these shifts with the antioxidant drug inhibits accumulation of LPO products and increases antioxidant defense and glucose absorption rate. These data prove the important role of peroxidation in regulation of glucose absorption.
Об авторах
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
S. Kolesnikov
Research Center of Family Health and Human Reproduction Problems; M. V. Lomonosov Moscow State University
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk; Moscow
L. Korytov
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
M. Suslikova
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
M. Darenskaya
Research Center of Family Health and Human Reproduction Problems
Автор, ответственный за переписку.
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Grebenkina
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: marina_darenskaya@inbox.ru
Россия, Irkutsk
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