Reparation and Immunomodulating Properties of Bacillus sp. Metabolites from Permafrost
- Autores: Kalenova L.1,2, Melnikov V.1,3,2, Besedin I.2, Bazhin A.2, Gabdulin M.2, Kolyvanova S.1,2
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Afiliações:
- Tyumen State University
- Tyumen Scientific Center of Siberian Division of Russian Academy of Science
- Tyumen Industrial University
- Edição: Volume 163, Nº 5 (2017)
- Páginas: 667-670
- Seção: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239180
- DOI: https://doi.org/10.1007/s10517-017-3875-y
- ID: 239180
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Resumo
An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp. at 37°C produced a potent therapeutic effect and promoted wound epithelialization by 30% in comparison with the control (ointment base) and by 20% in comparison with Solcoseryl. Treatment with Bacillus sp. metabolites stimulated predominantly humoral immunity, reduced the time of wound contraction and the volume of scar tissue, and promoted complete hair recovery. These metabolites can be considered as modulators of the wound process with predominance of regeneration mechanisms.
Sobre autores
L. Kalenova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Autor responsável pela correspondência
Email: lkalenova@mail.ru
Rússia, Tyumen; Tyumen
V. Melnikov
Tyumen State University; Tyumen Industrial University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Rússia, Tyumen; Tyumen; Tyumen
I. Besedin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Rússia, Tyumen
A. Bazhin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Rússia, Tyumen
M. Gabdulin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Rússia, Tyumen
S. Kolyvanova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Rússia, Tyumen; Tyumen