Reparation and Immunomodulating Properties of Bacillus sp. Metabolites from Permafrost
- Authors: Kalenova L.F.1,2, Melnikov V.P.1,3,2, Besedin I.M.2, Bazhin A.S.2, Gabdulin M.A.2, Kolyvanova S.S.1,2
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Affiliations:
- Tyumen State University
- Tyumen Scientific Center of Siberian Division of Russian Academy of Science
- Tyumen Industrial University
- Issue: Vol 163, No 5 (2017)
- Pages: 667-670
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239180
- DOI: https://doi.org/10.1007/s10517-017-3875-y
- ID: 239180
Cite item
Abstract
An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp. at 37°C produced a potent therapeutic effect and promoted wound epithelialization by 30% in comparison with the control (ointment base) and by 20% in comparison with Solcoseryl. Treatment with Bacillus sp. metabolites stimulated predominantly humoral immunity, reduced the time of wound contraction and the volume of scar tissue, and promoted complete hair recovery. These metabolites can be considered as modulators of the wound process with predominance of regeneration mechanisms.
About the authors
L. F. Kalenova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Author for correspondence.
Email: lkalenova@mail.ru
Russian Federation, Tyumen; Tyumen
V. P. Melnikov
Tyumen State University; Tyumen Industrial University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Russian Federation, Tyumen; Tyumen; Tyumen
I. M. Besedin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Russian Federation, Tyumen
A. S. Bazhin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Russian Federation, Tyumen
M. A. Gabdulin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Russian Federation, Tyumen
S. S. Kolyvanova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Russian Federation, Tyumen; Tyumen