Reparation and Immunomodulating Properties of Bacillus sp. Metabolites from Permafrost
- Авторы: Kalenova L.1,2, Melnikov V.1,3,2, Besedin I.2, Bazhin A.2, Gabdulin M.2, Kolyvanova S.1,2
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Учреждения:
- Tyumen State University
- Tyumen Scientific Center of Siberian Division of Russian Academy of Science
- Tyumen Industrial University
- Выпуск: Том 163, № 5 (2017)
- Страницы: 667-670
- Раздел: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239180
- DOI: https://doi.org/10.1007/s10517-017-3875-y
- ID: 239180
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Аннотация
An ointment containing metabolites of Bacillus sp. microorganisms isolated from permafrost samples was applied onto the skin wound of BALB/c mice. Metabolites isolated during culturing of Bacillus sp. at 37°C produced a potent therapeutic effect and promoted wound epithelialization by 30% in comparison with the control (ointment base) and by 20% in comparison with Solcoseryl. Treatment with Bacillus sp. metabolites stimulated predominantly humoral immunity, reduced the time of wound contraction and the volume of scar tissue, and promoted complete hair recovery. These metabolites can be considered as modulators of the wound process with predominance of regeneration mechanisms.
Об авторах
L. Kalenova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Автор, ответственный за переписку.
Email: lkalenova@mail.ru
Россия, Tyumen; Tyumen
V. Melnikov
Tyumen State University; Tyumen Industrial University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Россия, Tyumen; Tyumen; Tyumen
I. Besedin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Россия, Tyumen
A. Bazhin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Россия, Tyumen
M. Gabdulin
Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Россия, Tyumen
S. Kolyvanova
Tyumen State University; Tyumen Scientific Center of Siberian Division of Russian Academy of Science
Email: lkalenova@mail.ru
Россия, Tyumen; Tyumen