Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development
- Autores: Zyuz’kov G.1,2, Losev E.1, Chaikovskii A.1, Suslov N.1, Zhdanov V.1, Udut E.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Povet’eva T.1, Nesterova Y.1, Stavrova L.1, Udut V.1,2, Minakova M.1, Dygai A.1
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Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Tomsk National Research State University
- Edição: Volume 161, Nº 1 (2016)
- Páginas: 45-49
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237078
- DOI: https://doi.org/10.1007/s10517-016-3341-2
- ID: 237078
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Resumo
Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
Sobre autores
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Autor responsável pela correspondência
Email: zgn@pharm.tsu.ru
Rússia, Tomsk; Tomsk
E. Losev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Email: zgn@pharm.tsu.ru
Rússia, Tomsk; Tomsk
M. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Rússia, Tomsk
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