Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development
- Authors: Zyuz’kov G.N.1,2, Losev E.A.1, Chaikovskii A.V.1, Suslov N.I.1, Zhdanov V.V.1, Udut E.V.1, Miroshnichenko L.A.1, Simanina E.V.1, Polyakova T.Y.1, Povet’eva T.N.1, Nesterova Y.V.1, Stavrova L.A.1, Udut V.V.1,2, Minakova M.Y.1, Dygai A.M.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Tomsk National Research State University
- Issue: Vol 161, No 1 (2016)
- Pages: 45-49
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237078
- DOI: https://doi.org/10.1007/s10517-016-3341-2
- ID: 237078
Cite item
Abstract
Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
About the authors
G. N. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Author for correspondence.
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk; Tomsk
E. A. Losev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
A. V. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
N. I. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
E. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
L. A. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
E. V. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
T. N. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
Yu. V. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
L. A. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
V. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk; Tomsk
M. Yu. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk