Мақаланы E-mail арқылы жіберу CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects
- Авторлар: Ivanova S.A.1,2, Filipenko M.L.3, Vyalova N.M.1, Voronina E.N.3, Pozhidaev I.V.1,4, Osmanova D.Z.1,4, Ivanov M.V.5, Fedorenko O.Y.1,2, Semke A.V.1, Bokhan N.A.1,4
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Мекемелер:
- Research Institute of Mental Health
- National Research Tomsk Polytechnical University
- Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
- National Research Tomsk State University
- St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
- Шығарылым: Том 160, № 5 (2016)
- Беттер: 687-690
- Бөлім: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/236892
- DOI: https://doi.org/10.1007/s10517-016-3250-4
- ID: 236892
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
Авторлар туралы
S. Ivanova
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Хат алмасуға жауапты Автор.
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk; Tomsk
M. Filipenko
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Ресей, Novosibirsk
N. Vyalova
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk
E. Voronina
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Ресей, Novosibirsk
I. Pozhidaev
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk; Tomsk
D. Osmanova
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk; Tomsk
M. Ivanov
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
Email: svetlana@mail.tomsknet.ru
Ресей, St. Petersburg
O. Fedorenko
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk; Tomsk
A. Semke
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk
N. Bokhan
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Ресей, Tomsk; Tomsk
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