Email this article CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects
- Authors: Ivanova S.A.1,2, Filipenko M.L.3, Vyalova N.M.1, Voronina E.N.3, Pozhidaev I.V.1,4, Osmanova D.Z.1,4, Ivanov M.V.5, Fedorenko O.Y.1,2, Semke A.V.1, Bokhan N.A.1,4
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Affiliations:
- Research Institute of Mental Health
- National Research Tomsk Polytechnical University
- Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
- National Research Tomsk State University
- St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
- Issue: Vol 160, No 5 (2016)
- Pages: 687-690
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/236892
- DOI: https://doi.org/10.1007/s10517-016-3250-4
- ID: 236892
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Abstract
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
About the authors
S. A. Ivanova
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Author for correspondence.
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk; Tomsk
M. L. Filipenko
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Russian Federation, Novosibirsk
N. M. Vyalova
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk
E. N. Voronina
Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: svetlana@mail.tomsknet.ru
Russian Federation, Novosibirsk
I. V. Pozhidaev
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk; Tomsk
D. Z. Osmanova
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk; Tomsk
M. V. Ivanov
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute, Ministry of Health of the Russian Federation
Email: svetlana@mail.tomsknet.ru
Russian Federation, St. Petersburg
O. Yu. Fedorenko
Research Institute of Mental Health; National Research Tomsk Polytechnical University
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk; Tomsk
A. V. Semke
Research Institute of Mental Health
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk
N. A. Bokhan
Research Institute of Mental Health; National Research Tomsk State University
Email: svetlana@mail.tomsknet.ru
Russian Federation, Tomsk; Tomsk
