Changes in Production of Cytokines by C57Bl/6J Mouse Spleen during Aggression Provoked by Social Stress
- Autores: Idova G.1, Markova E.2, Gevorgyan M.1, Alperina E.1, Zhukova E.1
-
Afiliações:
- Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
- Department of Neuroimmunology, State Research Institute of Fundamental and Clinical Immunology
- Edição: Volume 160, Nº 5 (2016)
- Páginas: 679-682
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236887
- DOI: https://doi.org/10.1007/s10517-016-3248-y
- ID: 236887
Citar
Resumo
The effect of aggressive behavior shaped under social stress of various durations on the production of proinflammatory cytokines by splenic cells was examined on C57BL/6J mice. Aggressive mice were characterized by enhanced production of IL-2 and IFN-γ (released by T helper type 1 cells) and reduced secretion of TNF-α, whose major producers are monocytes and macrophages. Elevation of IL-2 and IFN-γ in aggressive mice resulted from enhancement of spontaneous and Con A-stimulated production, the most pronounced effect was demonstrated by the with a longer period (20 days) of victories. In contrast, spontaneous production of TNF-α was similar in control and aggressive mice, although LPS-stimulated production of this cytokine decreased after 10- and 20-day stress. The possible mechanisms of the changes in cytokine production are discussed.
Sobre autores
G. Idova
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Autor responsável pela correspondência
Email: galina@physiol.ru
Rússia, Novosibirsk
E. Markova
Department of Neuroimmunology, State Research Institute of Fundamental and Clinical Immunology
Email: galina@physiol.ru
Rússia, Novosibirsk
M. Gevorgyan
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
Rússia, Novosibirsk
E. Alperina
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
Rússia, Novosibirsk
E. Zhukova
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
Rússia, Novosibirsk