Changes in Production of Cytokines by C57Bl/6J Mouse Spleen during Aggression Provoked by Social Stress
- 作者: Idova G.1, Markova E.2, Gevorgyan M.1, Alperina E.1, Zhukova E.1
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隶属关系:
- Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
- Department of Neuroimmunology, State Research Institute of Fundamental and Clinical Immunology
- 期: 卷 160, 编号 5 (2016)
- 页面: 679-682
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236887
- DOI: https://doi.org/10.1007/s10517-016-3248-y
- ID: 236887
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详细
The effect of aggressive behavior shaped under social stress of various durations on the production of proinflammatory cytokines by splenic cells was examined on C57BL/6J mice. Aggressive mice were characterized by enhanced production of IL-2 and IFN-γ (released by T helper type 1 cells) and reduced secretion of TNF-α, whose major producers are monocytes and macrophages. Elevation of IL-2 and IFN-γ in aggressive mice resulted from enhancement of spontaneous and Con A-stimulated production, the most pronounced effect was demonstrated by the with a longer period (20 days) of victories. In contrast, spontaneous production of TNF-α was similar in control and aggressive mice, although LPS-stimulated production of this cytokine decreased after 10- and 20-day stress. The possible mechanisms of the changes in cytokine production are discussed.
作者简介
G. Idova
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
编辑信件的主要联系方式.
Email: galina@physiol.ru
俄罗斯联邦, Novosibirsk
E. Markova
Department of Neuroimmunology, State Research Institute of Fundamental and Clinical Immunology
Email: galina@physiol.ru
俄罗斯联邦, Novosibirsk
M. Gevorgyan
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
俄罗斯联邦, Novosibirsk
E. Alperina
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
俄罗斯联邦, Novosibirsk
E. Zhukova
Department of Neurochemical Modulatory Mechanisms, State Research Institute of Physiology and Fundamental Medicine
Email: galina@physiol.ru
俄罗斯联邦, Novosibirsk