Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats
- Autores: Ozerov A.1, Bagmetova V.1, Chernysheva Y.1, Tyurenkov I.1
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Afiliações:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 160, Nº 5 (2016)
- Páginas: 649-652
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236859
- DOI: https://doi.org/10.1007/s10517-016-3240-6
- ID: 236859
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Resumo
A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally). This effect manifested in suppression of depression-like behavior in the Porsolt forced swimming test (shortening of immobility time and increase in immobility latency, number of jumping episodes, and time of active swimming) and sucrose consumption/preference test (increase in the consumption of 20% sucrose solution in g/100 g body weight and percentage of sucrose preference in relation to the total fluid preference). Adeprophen had a greater antidepressant effect than sertraline and fluoxetine, but was less potent than amitriptyline, imipramine, venlafaxine, and to a lesser extent to paroxetine.
Sobre autores
A. Ozerov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Rússia, Volgograd
V. Bagmetova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: vvbagmetova@gmail.com
Rússia, Volgograd
Yu. Chernysheva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Rússia, Volgograd
I. Tyurenkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Rússia, Volgograd