Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats
- Authors: Ozerov A.A.1, Bagmetova V.V.1, Chernysheva Y.V.1, Tyurenkov I.N.1
-
Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 160, No 5 (2016)
- Pages: 649-652
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236859
- DOI: https://doi.org/10.1007/s10517-016-3240-6
- ID: 236859
Cite item
Abstract
A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally). This effect manifested in suppression of depression-like behavior in the Porsolt forced swimming test (shortening of immobility time and increase in immobility latency, number of jumping episodes, and time of active swimming) and sucrose consumption/preference test (increase in the consumption of 20% sucrose solution in g/100 g body weight and percentage of sucrose preference in relation to the total fluid preference). Adeprophen had a greater antidepressant effect than sertraline and fluoxetine, but was less potent than amitriptyline, imipramine, venlafaxine, and to a lesser extent to paroxetine.
About the authors
A. A. Ozerov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Russian Federation, Volgograd
V. V. Bagmetova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: vvbagmetova@gmail.com
Russian Federation, Volgograd
Yu. V. Chernysheva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Russian Federation, Volgograd
I. N. Tyurenkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: vvbagmetova@gmail.com
Russian Federation, Volgograd