Role of Glutathione System Redox Potential in Apoptosis Dysregulation in MCF-7 Breast Adenocarcinoma
- Autores: Shakhristova E.1, Stepovaya E.1, Ryazantseva N.2, Nosareva O.1, Yakushina V.1, Ivanov V.1, Novitskii V.1
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Afiliações:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Siberian Federal University
- Edição: Volume 160, Nº 3 (2016)
- Páginas: 364-367
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236708
- DOI: https://doi.org/10.1007/s10517-016-3172-1
- ID: 236708
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Resumo
MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
Sobre autores
E. Shakhristova
Siberian State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: shaxristova@yandex.ru
Rússia, Tomsk
E. Stepovaya
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Rússia, Tomsk
N. Ryazantseva
Siberian Federal University
Email: shaxristova@yandex.ru
Rússia, Krasnoyarsk
O. Nosareva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Rússia, Tomsk
V. Yakushina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Rússia, Tomsk
V. Ivanov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Rússia, Tomsk
V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Rússia, Tomsk